| Date | Location | Result | |
| 02/26/22 | Bloomington, IL | Elmhurst 82, North Central 65 | Box score |
| 02/25/22 | Bloomington, IL | North Central 81, Ill. Wesleyan 74 | Box score |
| 02/22/22 | Naperville, Ill. (Gregory Arena) | North Central 57, Millikin 50 | Box score |
| 02/16/22 | Bloomington, IL | Ill. Wesleyan 78, North Central 65 | Box score |
| 02/12/22 | Naperville, IL | North Central 68, Carroll (WI) 53 | Box score |
| 02/09/22 | Chicago, IL | North Park 62, North Central 58 | Box score |
| 02/07/22 | Naperville, Ill. (Gregory Arena) | North Central 61, Millikin 55 | Box score |
| 02/05/22 | Elmhurst, IL | Elmhurst 86, North Central 67 | Box score |
| 01/31/22 | Naperville, Ill. (Gregory Arena) | North Central 90, North Park 59 | Box score |
| 01/29/22 | Naperville, Ill. (Gregory Arena) | Wheaton 75, North Central 71 | Box score |
| 01/26/22 | Naperville, Ill. (Gregory Arena) | North Central 73, Augustana (IL) 68 | Box score |
| 01/24/22 | Naperville, Ill. (Gregory Arena) | North Central 79, Elmhurst 70 | Box score |
| 01/22/22 | Kenosha, WI | North Central 90, Carthage 79 | Box score |
| 01/19/22 | Waukesha, WI | North Central 89, Carroll (WI) 81 | Box score |
| 01/17/22 | Rock Island, IL | North Central 86, Augustana (IL) 82 | Box score |
| 01/15/22 | Wheaton, IL | Wheaton (IL) 83, North Central 79 | Box score |
| 12/28/21 | Hope 89, North Central 84 (OT) | Box score | |
| 12/22/21 | Cutler Event Center; Olivet, Michigan | North Central 88, Olivet 70 | Box score |
| 12/21/21 | Anderson Athletic Center, Kalamazoo, MI | North Central (Ill.) 84, Kalamazoo 73 | Box score |
| 12/18/21 | Decatur, IL | North Central 70, Millikin 67 (2OT) | Box score |
| 12/15/21 | Naperville, IL | Ill. Wesleyan 73, North Central 48 | Box score |
| 12/11/21 | Kolf Sports Center - Oshkosh, Wis. | UW-Oshkosh 91, North Central 67 | Box score |
| 12/04/21 | Naperville, IL | North Central 91, Carthage 59 | Box score |
| 11/27/21 | Naperville, IL | North Central 76, Aurora 44 | Box score |
| 11/23/21 | Lisle, IL | North Central 65, Benedictine (IL) 62 | Box score |
| 11/13/21 | Greenville, IL | North Central 137, Greenville 108 | Box score |
| 11/10/21 | Naperville, Ill. (Gregory Arena) | Cal Lutheran 80, North Central 79 | Box score |